Françoise Stutz - Director
We are interested in the effect of pervasive non-coding transcription on gene regulation and the replication initiation program. Another focus is the importance of nuclear organization in mRNA biogenesis and export through nuclear pores as well as the mechanisms underlying the resolution of DNA-protein cross-links deleterious to genome stability.
Our focus is the biology of vertebrate cell-cell junctions. Specifically, we study the structure and function of junctional proteins, the molecular mechanisms through which junctions are implicated in signalling to control cell and tissue behaviour, and their roles in physiology and disease.
The lab focuses on deciphering the structural mechanisms governing centriole assembly. To this end, we are combining the use of cell biology methods, in vitro reconstitution assays and state-of-the art imaging technologies to gain decisive insights into these mechanisms.
Mitochondria play an essential role in cell homeostasis. Research in the lab is currently focused on two main areas: understanding the control of mitochondrial gene expression and investigating the pivotal role of pyruvate metabolism in neuronal activity and in carcinogenesis.