Françoise Stutz Laboratory
My lab studies the process of mRNA biogenesis and export through nuclear pores, and the importance of nuclear architecture in gene expression. Another topic concerns the role of non-coding antisense RNAs in transcriptional gene silencing.
Current research can be divided into 3 variations on the theme RNA:
- Role of ubiquitin in the regulation of mRNP dynamics and export through nuclear pores.
- Functional relationship between gene expression and intra-nuclear gene positioning: role of nuclear pores in transcription regulation?
- Importance of non-coding and antisense RNAs in epigenetic control of gene expression through RNAi independent mechanisms.
The aspartic protease Ddi1 contributes to DNA-protein crosslink repair in yeast.Molecular Cell 2020, https://doi.org/10.1016/j.molcel.2019.12.007.
The mRNA export adaptor Yra1 contributes to DNA double-strand break repair through its C-box domain. Infantino V, Tutucci E, Yeh Martin N, Zihlmann A, Garcia-Molinero V, Silvano G, Palancade B, Stutz F. PLoS One. 2019 Apr 5. https://doi.org/10.1371/journal.pone.0206336
Noncoding transcription influences the replication initiation program through chromatin regulation. Soudet J+, Gill JK, Stutz F+. Genome Res. 2018 Dec;28(12):1882-1893. doi: 10.1101/gr.239582.118. Epub 2018 Nov 6.