Jean-Claude Martinou

Publications

2020

Mitochondrial RNA granules are fluid condensates, positioned by membrane dynamicsRey T.*Zaganelli S.*Cuillery E., Martinou JC, Manley. S.†. BiorXiv. Submitted

The mitochondrial carrier pathway transports non-canonical substrates with an odd number of transmembrane segments. Rampelt H, Sucec I, Bersch B, Horten P, Perschil I, Martinou JC, van der Laan M, Wiedemann N, Schanda P, Pfanner N. BMC Biol. 2020 Jan 6

Development and validation of a chiral UHPLC-MS method for the analysis of cysteine enantiomers in biological samples. Pucciarini L, González-Ruiz V, Zangari J, Martinou JC, Natalini B, Sardella R, Rudaz S. J Pharm Biomed Anal. 2019 Aug 27

2019

In vivo stabilization of OPA1 in hepatocytes potentiates mitochondrial respiration and gluconeogenesis in a prohibitin-dependent way. Li L, Martin-Levilain J, Jiménez-Sánchez C, Karaca M, Foti M, Martinou JC, Maechler P. J Biol Chem. 2019 Jul 8. 

Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate. Sica V, Bravo-San Pedro JM, Izzo V, Pol J, Pierredon S, Enot D, Durand S, Bossut N, Chery A, Souquere S, Pierron G, Vartholomaiou E, Zamzami N, Soussi T, Sauvat A, Mondragón L, Kepp O, Galluzzi L, Martinou JC, Hess-Stumpp H, Ziegelbauer K, Kroemer G, Maiuri MC. Cell Rep. 2019 Apr 16

The yeast mitochondrial pyruvate carrier is a hetero-dimer in its functional state. Tavoulari S, Thangaratnarajah C, Mavridou V, Harbour ME, Martinou JC, Kunji ER. EMBO J. 2019 Apr 12.

2018

Mitochondria-specific photoactivation to monitor local sphingosine metabolism and function. Feng S, Harayama T, Montessuit S, David FP, Winssinger N, Martinou JC, Riezman H. elife. 2018 Jan 29

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Galluzzi Let al. Cell Death Differ. 2018 Mar;25

2017

The FASTK family of proteins: emerging regulators of mitochondrial RNA biology. Jourdain AA, Popow J, de la Fuente MA, Martinou JC, Anderson P, Simarro M. Nucleic Acids Res. 2017 Nov 2

Efficient Mitochondrial Glutamine Targeting Prevails Over Glioblastoma Metabolic Plasticity. Oizel K, Chauvin C, Oliver L, Gratas C, Geraldo F, Jarry U, Scotet E, Rabe M, Alves-Guerra MC, Teusan R, Gautier F, Loussouarn D, Compan V, Martinou JC, Vallette FM, Pecqueur C. Clin Cancer Res. 2017 Oct 15

FASTKD1 and FASTKD4 have opposite effects on expression of specific mitochondrial RNAs, depending upon their endonuclease-like RAP domain. Boehm E, Zaganelli S, Maundrell K, Jourdain AA, Thore S, Martinou JC. Nucleic Acids Res. 2017 Jun 2

The Pseudouridine Synthase RPUSD4 Is an Essential Component of Mitochondrial RNA Granules. Zaganelli S, Rebelo-Guiomar P, Maundrell K, Rozanska A, Pierredon S, Powell CA, Jourdain AA, Hulo N, Lightowlers RN, Chrzanowska-Lightowlers ZM, Minczuk M, Martinou JC. J Biol Chem. 2017 Mar 17

2016

Role of FAST Kinase Domains 3 (FASTKD3) in Post-transcriptional Regulation of Mitochondrial Gene Expression. Boehm E, Zornoza M, Jourdain AA, Delmiro Magdalena A, García-Consuegra I, Torres Merino R, Orduña A, Martín MA, Martinou JC, De la Fuente MA, Simarro M. J Biol Chem. 2016 Dec 9

Solange Desagher and Jean-Claude Martinou: Executioners of Cell Death. Desagher S, Martinou JC. Trends Cell Biol. 2016 Aug

MPC1-like Is a Placental Mammal-specific Mitochondrial Pyruvate Carrier Subunit Expressed in Postmeiotic Male Germ Cells. Vanderperre B, Cermakova K, Escoffier J, Kaba M, Bender T, Nef S, Martinou JC. J Biol Chem. 2016 Aug 5

Channels and transporters in cell metabolism. Sonveaux P, Maechler P, Martinou JC. Biochim Biophys Acta. 2016 Oct

Embryonic Lethality of Mitochondrial Pyruvate Carrier 1 Deficient Mouse Can Be Rescued by a Ketogenic Diet. Vanderperre B, Herzig S, Krznar P, Hörl M, Ammar Z, Montessuit S, Pierredon S, Zamboni N, Martinou JC. PLoS Genet. 2016 May 13

Mitochondrial RNA granules: Compartmentalizing mitochondrial gene expression. Jourdain AA, Boehm E, Maundrell K, Martinou JC. J Cell Biol. 2016 Mar 14

The mitochondrial pyruvate carrier in health and disease: To carry or not to carry? Bender T, Martinou JC. Biochim Biophys Acta. 2016 Oct. Review.

TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL. Thébault S, Agez M, Chi X, Stojko J, Cura V, Telerman SB, Maillet L, Gautier F, Billas-Massobrio I, Birck C, Troffer-Charlier N, Karafin T, Honoré J, Senff-Ribeiro A, Montessuit S, Johnson CM, Juin P, Cianférani S, Martinou JC, Andrews DW, Amson R, Telerman A, Cavarelli J. Sci Rep. 2016 Jan 27

Raemy E, Montessuit S, Pierredon S, van Kampen AH, Vaz FM, Martinou JC. Cardiolipin or MTCH2 can serve as tBID receptors during apoptosis. Cell Death Differ. 2016 Jan 22. doi: 10.1038/cdd.2015.166.

2015

Compan V, Pierredon S, Vanderperre B, Krznar P, Marchiq I, Zamboni N, Pouyssegur J, Martinou J-C. Monitoring mitochondrial pyruvate carrier activity in real time using a BRET-based biosensor: investigation of the Warburg effect. Mol Cell. 2015 Aug 6;59(3):491-501. doi: 10.1016/j.molcel.2015.06.035.

Jourdain AA, Koppen M, Rodley CD, Maundrell K, Gueguen N, Reynier P, Guaras AM, Enriquez JA, Anderson P, Simarro M and Martinou JC. A mitochondria-specific isoform of FASTK is present in mitochondrial RNA granules and regulates gene expression and function. Cell Reports 2015 Feb 17.

Bender T, Pena G, Martinou JC. Regulation of mitochondrial pyruvate uptake by alternative pyruvate carrier complexes. EMBO J. 2015 Feb 11. pii: e201490197.

2014

Vanderperre B, Bender T, Kunji ER, Martinou JC. Mitochondrial pyruvate import and its effects on homeostasis. Curr Opin Cell Biol. 2014 Nov 15;33C:35-41.

Bustillo-Zabalbeitia I, Montessuit S, Raemy E, Basañez G, Terrones O, Martinou JC. Specific Interaction with Cardiolipin Triggers Functional Activation of Dynamin-Related Protein 1. PLoS One. 2014 Jul 18;9(7):e102738.

Raemy E, Martinou JC. Involvement of cardiolipin in tBID-induced activation of Bax during apoptosis. Chem Phys Lipids. 2014 Apr;179:70-4. doi: 10.1016/j.chemphyslip.2013.12.002. Epub 2013 Dec 12.

2013

Herzig S., Maundrell K., Martinou JC. Life without the mitochondrial calcium uniporter. Nature Cell Biology. (2013) 15,1398–1400

Jourdain AA, Koppen M, Wydro M., Rodley CD, Lightowlers RN, Chrzanowska-Lightowlers ZM, Martinou JC. GRSF1 regulates RNA processing in mitochondrial RNA granules. Cell Metabolism. 2013 Mar 5;17(3):399-410.

Bender T, Martinou JC. Where Killers Meet--Permeabilization of the Outer Mitochondrial Membrane during Apoptosis. Cold Spring Harb Perspect Biol. 2013 Jan 1;5(1).

2012

Somasekharan SP, Koc M, Morizot A, Micheau O, Sorensen PH, Gaide O, Andera L, Martinou JC. TRAIL promotes membrane blebbing, detachment and migration of cells displaying a dysfunctional intrinsic pathway of apoptosis. Apoptosis. 2012 Nov 21.

Herzig S., Raemy E., Montessuit S., Veuthey JL, Zamboni N., Westermann B., Kunji ERS and Martinou JC. Identification and Functional Expression of the Mitochondrial Pyruvate Carrier. Science. 2012 Jul 6;337(6090):93-6. 2012 May 24.

2011

Martinou JC, Youle RJ. Mitochondria in apoptosis: bcl-2 family members and mitochondrial dynamics. Dev Cell. 2011 Jul 19;21(1):92-101.

Landes T, Martinou JC. Mitochondrial outer membrane permeabilization during apoptosis: the role of mitochondrial fission. Biochim Biophys Acta. 2011 Jan 27.

2010

Martinou JC. Mitochondrial dynamics: from geometry to function. Med Sci (Paris). 2010 Oct;26(10):783-5.

Montessuit S, Somasekharan SP, Terrones O, Lucken-Ardjomande S, Herzig S, Schwarzenbacher R, Manstein DJ, Bossy-Wetzel E, Basañez G, Meda P, Martinou JC. Membrane remodeling induced by the dynamin-related protein drp1 stimulates bax oligomerization. Cell. 2010 Sep 17;142(6):889-901.

Jourdain A, Martinou JC. Mitochondrial dynamics: quantifying mitochondrial fusion in vitro. BMC Biol. 2010 Jul 26;8:99.

Cartoni R, Arnaud E, Médard JJ, Poirot O, Courvoisier DS, Chrast R and Martinou JC. Expression of Mitofusin 2 R94Q in a transgenic mouse leads to Charcot-Marie-Tooth neuropathy type 2A. Brain. 2010 May;133(Pt 5):1460-9.

Before 2010

Martinou JC, Kroemer G. Autophagy: Evolutionary and pathophysiological insights. Biochim Biophys Acta. 2009 Sep;1793(9):1395-1396.

Cartoni R and Martinou JC. Role of mitofusin 2 mutations in the physiopathology of Charcot-Marie-Tooth disease type 2A. Exp Neurol. 2009 May 8.

Jourdain A and Martinou JC. Mitochondrial outer membrane permeabilization and remodeling in apoptosis. Int J Biochem Cell Biol. 2009 May 9.

Tondera D, Grandemange S, Jourdain A, Karbowski M, Mattenberger Y, Herzig S, Da Cruz S, Clerc P, Raschke I, Merkwirth C, Ehses S, Krause F, Chan DC, Alexander C, Bauer C, Youle R, Langer T, Martinou JC. SLP-2 is required for stress-induced mitochondrial hyperfusion. EMBO J. 2009 Jun 3;28(11):1589-600.

Menuz V, Howell KS, Gentina S, Epstein S, Riezman I, Fornallaz-Mulhauser M, Hengartner MO, Gomez M, Riezman H, Martinou JC. Protection of C. elegans from Anoxia by HYL-2 Ceramide Synthase. Science. 2009 Apr 17;324(5925):381-4.

Grandemange S, Herzig S, Martinou JC. Mitochondrial dynamics and cancer. Semin Cancer Biol. 2008 Dec 24.

James DI, Martinou JC. Mitochondrial dynamics and apoptosis: a painful separation. Dev Cell. 2008 Sep;15(3):341-3.

Parone PA, Da Cruz S, Tondera D, Mattenberger Y, James DI, Maechler P, Barja F, Martinou JC. Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA. PLoS ONE. 2008 Sep 22

Lucken-Ardjomande S, Martinou JC. Granzyme a, a stealth killer in the mitochondrion. Cell, 2008.

Da Cruz S, Martinou JC. Purification and proteomic analysis of the mouse liver mitochondrial inner membrane. Methods Mol Biol. 2008;432:101-16.

Lucken-Ardjomande S, Montessuit S, Martinou JC. Contributions to Bax insertion and oligomerization of lipids of the mitochondrial outer membrane. Cell Death Differ. 2008 Feb 8.

Da Cruz S, Parone PA, Gonzalo P, Bienvenut W, Tondera D, Jourdain A, Quadroni M, Martinou JC. SLP-2 interacts with prohibitins in the mitochondrial inner membrane and contributes to their stability. BBA Mol Cell Res, 2008 Feb 20.

Herzig S, Martinou JC. Mitochondrial dynamics: to be in good shape to survive. Current Molecular Medicine, 2008 Mar 8.

Lucken-Ardjomande S, Montessuit S, Martinou JC. Bax activation and stress-induced apoptosis delayed by the accumulation of cholesterol in mitochondrial membranes. Cell Death Differ. 2008 Mar;15(3):484-93. Dec 14.

James D, Parone PA, Terradillos O, Lucken-Ardjomande S, Montessuit S, Martinou JC. Mechanisms of mitochondrial outer membrane permeabilization. Novartis Found Symp. 2007;287:170-6; discussion 176-82.

Alirol E, James D, Huber D, Marchetto A, Vergani L, Martinou JC, Scorrano L. The mitochondrial fission protein hFis1 requires the endoplasmic reticulum gateway to induce apoptosis. Mol Biol Cell. 2006 Nov;17(11):4593-605.

Parone PA, Martinou JC. Mitochondrial fission and apoptosis: an ongoing trial. Biochim Biophys Acta. 2006 May-Jun;1763(5-6):522-30. Epub 2006 Apr 20.

Martinou JC, Youle RJ. Which came first, the cytochrome c release or the mitochondrial fission? Cell Death Differ. 2006 Aug;13(8):1291-5. Epub 2006 Jun 9.

Alirol E, Martinou JC. Mitochondria and cancer: is there a morphological connection? Oncogene. 2006 Aug 7;25(34):4706-16.

Parone PA, James DI, Da Cruz S, Mattenberger Y, Donze O, Barja F, Martinou JC. Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis. Mol Cell Biol. 2006 Oct;26(20):7397-408.

Priault M, Salin B, Schaeffer J, Vallette FM, di Rago JP, Martinou JC. Impairing the bioenergetic status and the biogenesis of mitochondria triggers mitophagy in yeast. Cell Death Differ. 2005 Dec;12(12):1613-21.

Lucken-Ardjomande S, Martinou JC. Newcomers in the process of mitochondrial permeabilization. J Cell Sci. 2005 Feb 1;118(Pt 3):473-83.

Lucken-Ardjomande S, Martinou JC. Regulation of Bcl-2 proteins and of the permeability of the outer mitochondrial membrane. C R Biol. 2005 Jul;328(7):616-31.

Da Cruz S, Parone PA, Martinou JC. Building the mitochondrial proteome. Expert Rev Proteomics. 2005 Aug;2(4):541-51.

Lucken-Ardjomande S, Montessuit S, Martinou JC. Changes in the outer mitochondrial membranes during apoptosis J Soc Biol. 2005;199(3):207-10.

Nothwehr SF, Martinou JC. A retention factor keeps death at bay. Nat Cell Biol. 2003 Apr;5(4):281-3.

James DI, Parone PA, Mattenberger Y, Martinou JC. hFis1, a novel component of the mammalian mitochondrial fission machinery. J Biol Chem. 2003 Sep 19;278(38):36373-9. Epub 2003 Jun 3. Erratum in: J Biol Chem. 2004 Aug 20;279(34):36166.

Parone P, Priault M, James D, Nothwehr SF, Martinou JC. Apoptosis: bombarding the mitochondria. Essays Biochem. 2003;39:41-51.

Mattenberger Y, James DI, Martinou JC. Fusion of mitochondria in mammalian cells is dependent on the mitochondrial inner membrane potential and independent of microtubules or actin. FEBS Lett. 2003 Mar 13;538(1-3):53-9.

Da Cruz S, Xenarios I, Langridge J, Vilbois F, Parone PA, Martinou JC. Proteomic analysis of the mouse liver mitochondrial inner membrane. J Biol Chem. 2003 Oct 17;278(42):41566-71. Epub 2003 Jul 15.

Parone PA, James D, Martinou JC. Mitochondria: regulating the inevitable. Biochimie. 2002 Feb-Mar;84(2-3):105-11.

Terradillos O, Montessuit S, Huang DC, Martinou JC. Direct addition of BimL to mitochondria does not lead to cytochrome c release. FEBS Lett. 2002 Jul 3

Roucou X, Montessuit S, Antonsson B, Martinou JC. Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein. Biochem J. 2002 Dec 15

Parone PA, James D, Martinou JC. Mitochondria: regulating the inevitable. Biochimie. 2002 Feb-Mar;84(2-3):105-11.

Martinou JC, Green DR. Breaking the mitochondrial barrier. Nat Rev Mol Cell Biol. 2001 Jan;2(1):63-7.

Roucou X, Martinou JC. Conformational change of Bax: a question of life or death. Cell Death Differ. 2001 Sep;8(9):875-7.

Desagher S, Osen-Sand A, Montessuit S, Magnenat E, Vilbois F, Hochmann A, Journot L, Antonsson B, Martinou JC. Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8. Mol Cell. 2001 Sep;8(3):601-11.

Roucou X, Antonsson B, Martinou JC. Involvement of mitochondria in apoptosis. Cardiol Clin. 2001 Feb;19(1):45-55.