Paul Guichard

Nikolai Klena

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Nikolai Klena

PhD student

2017
+41 22 379 6723
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Publications

Isolation, Imaging and fluorescent single particle reconstruction of  Chlamydomonas  centrioles . Klena N.§, Gambarotto D. §, Le Guennec M. , Borgers S., Guichard P.*, Hamel V.* JoVE(139), e58109, doi:10.3791/58109

 

Role of Cilia and Left-Right Patterning in Congenital Heart Disease. Klena NGabriel GLiu XYagi HLi YChen YZahid MTobita KLeatherbury LPazour GLo CW. in Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology . Tokyo: Springer; 2016. Chapter 8.  2016 Jun 25.

 

The complex genetics of hypoplastic left heart syndrome. Liu XYagi HSaeed SBais ASGabriel GCChen ZPeterson KALi YSchwartz MCReynolds WTSaydmohammed MGibbs BWu YDevine WChatterjee BKlena NTKostka Dde Mesy Bentley KLGanapathiraju MKDexheimer PLeatherbury LKhalifa OBhagat AZahid MPu WWatkins SGrossfeld PMurray SAPorter GA JrTsang MMartin LJBenson DWAronow BJLo CWNat Genet. 2017 Jul;49(7):1152-1159. 

 

Assessment of ciliary phenotype in primary ciliary dyskinesia by micro-optical coherence tomography. Solomon GMFrancis RChu KKBirket SEGabriel GTrombley JELemke KLKlena NTurner BTearney GJLo CWRowe SMJCI Insight. 2017 Mar 9;2(5):e91702. 

 

Cilia and Ciliopathies in Congenital Heart Disease. Klena NTGibbs BCLo CWCold Spring Harb Perspect Biol. 2017 Aug 1;9(8). pii: a028266. 

 

Genetic link between renal birth defects and congenital heart disease. San Agustin JTKlena NGranath KPanigrahy AStewart EDevine WStrittmatter LJonassen JALiu XLo CWPazour GJNat Commun. 2016 Mar 22;7:11103. 

 

Discovery of four recessive developmental disorders using probabilistic genotype and phenotype matching among 4,125 families. Akawi NMcRae JAnsari MBalasubramanian MBlyth MBrady AFClayton SCole TDeshpande CFitzgerald TWFoulds NFrancis RGabriel GGerety SSGoodship JHobson EJones WDJoss SKing DKlena NKumar ALees MLelliott CLord JMcMullan DO'Regan MOsio DPiombo VPrigmore ERajan DRosser ESifrim ASmith ASwaminathan GJTurnpenny PWhitworth JWright CFFirth HVBarrett JCLo CWFitzPatrick DRHurles MEDDD studyNat Genet. 2015 Nov;47(11):1363-9. 

 

MMP21 is mutated in human heterotaxy and is required for normal left-right asymmetry in vertebrates. Guimier AGabriel GCBajolle FTsang MLiu HNoll ASchwartz MEl Malti RSmith LDKlena NTJimenez GMiller NAOufadem MMoreau de Bellaing AYagi HSaunders CJBaker CNDi Filippo SPeterson KAThiffault IBole-Feysot CCooley LDFarrow EGMasson CSchoen PDeleuze JFNitschké PLyonnet Sde Pontual LMurray SABonnet DKingsmore SFAmiel JBouvagnet PLo CWGordon CTNat Genet. 2015 Nov;47(11):1260-3. 

 

Respiratory motile cilia dysfunction in a patient with cranioectodermal dysplasia. Li YGarrod ASMadan-Khetarpal SSreedher GMcGuire MYagi HKlena NTGabriel GCKhalifa OZahid MPanigrahy AWeiner DJLo CWAm J Med Genet A. 2015 Sep;167A(9):2188-96. 

 

Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Li Y*Klena NT*Gabriel GCLiu XKim AJLemke KChen YChatterjee BDevine WDamerla RRChang CYagi HSan Agustin JTThahir MAnderton SLawhead CVescovi APratt HMorgan JHaynes LSmith CLEppig JTReinholdt LFrancis RLeatherbury LGanapathiraju MKTobita KPazour GJLo CWNature. 2015 May 28;521(7553):520-4. 

 

ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning. Czarnecki PGGabriel GCManning DKSergeev MLemke KKlena NTLiu XChen YLi YSan Agustin JTGarnaas MKFrancis RJTobita KGoessling WPazour GJLo CWBeier DRShah JVNat Commun. 2015 Jan 20;6:6023. 

 

CCDC151 mutations cause primary ciliary dyskinesia by disruption of the outer dynein arm docking complex formation. Hjeij ROnoufriadis AWatson CMSlagle CEKlena NTDougherty GWKurkowiak MLoges NTDiggle CPMorante NFGabriel GCLemke KLLi YPennekamp PMenchen TKonert FMarthin JKMans DALetteboer SJWerner CBurgoyne TWestermann CRutman ACarr IMO'Callaghan CMoya EChung EMUK10K ConsortiumSheridan ENielsen KGRoepman RBartscherer KBurdine RDLo CWOmran HMitchison HMAm J Hum Genet. 2014 Sep 4;95(3):257-74. 

 

Role of cilia in structural birth defects: insights from ciliopathy mutant mouse models. Rao Damerla RGabriel GCLi YKlena NTLiu XChen YCui CPazour GJLo CWBirth Defects Res C Embryo Today. 2014 Jun;102(2):115-25. doi: 10.1002/bdrc.21067. Review.

 

Cyclic Di-GMP phosphodiesterases RmdA and RmdB are involved in regulating colony morphology and development in Streptomyces coelicolor. Hull TDRyu MHSullivan MJJohnson RCKlena NTGeiger RMGomelsky MBennett JAJ Bacteriol. 2012 Sep;194(17):4642-51. doi: 10.1128/JB.00157-12. Epub 2012 Jun 29.