Guichard / Hamel

Virginie Hamel

Dr. Virginie Hamel

Co-group leader - Collaboratrice Scientifique

+41 22 379 6735


Since 2015 - Co-group leader, UNIGE

2012-2015 - Staff Scientist at EPFL (Pierre Gonczy's lab)

2005- 2012 - Post-doc at EPFL (Pierre Gonczy's lab)

2004 - PhD at EMBL (Iain Mattaj's lab)



2008-2010 -  Marie Heim Vögtlin fellowshio (SNSF fellowship)

2008-2009 - Roche foundation fellowship

2005-2008 - FEBS longterm fellowship

2003-2004 - EMBL Fellowship



20. A helical inner scaffold provides a structural basis for centriole cohesion. Le Guennec M, Klena N., Gambarotto D., Laporte MH , Tassin AM, Van den Hoek H., Erdmann PS, Schaffer M., Kovacik L., Borgers S., Goldie KN, Stahlberg H., Bornens M., Azimzadeh J., Engel BD#, Hamel V.* and Guichard P.Science Advances. Feb 2020


19. Flagellar microtubule doublet assembly in vitro reveals a regulatory role of tubulin C-terminal tails. M. Schmidt-Cernohorska, I. Zhernov, E. Steib, M. Le Guennec1, R. Achek, S. Borgers, D. Demurtas, L. Mouawad, Z. Lansky, V. Hamel* and P. Guichard*. Science. Jan 2019


18. Imaging cellular ultrastructures using expansion microscopy (U-ExM).  Gambarotto D. ##, Zwettler F. U. ##, Le Guennec M., Schmidt-Cernohorska M. , Fortun D. , Borgers  S. , Heine J. , Schloetel J. G. , Reuss M. , Unser M. , Boyden E.S. , Sauer M. *, Hamel V. * and  Guichard P.*. Nature Methods. 2019


17. Isolation, Imaging and fluorescent single particle reconstruction of  Chlamydomonas  centrioles . Klena N.§, Gambarotto D. §, Le Guennec M. , Borgers S., Guichard P.*, Hamel V.JoVE(139), e58109, doi:10.3791/58109


16. Reconstruction From Multiple Particles for 3D Isotropic Resolution in Fluorescence Microscopy. Fortun DGuichard PHamel VSorzano COSBanterle NGonczy PUnser MIEEE Trans Med Imaging. 2018 May;37(5):1235-1246. 


15.  Rise of the Cartwheel: Seeding the Centriole Organelle. Guichard PHamel VGönczy PBioessays. 2018 Apr;40(4):e1700241. 


14. Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis. Hamel V, Steib EHamelin RArmand FBorgers SFlückiger IBusso COlieric NSorzano COSSteinmetz MOGuichard P*Gönczy P.* Curr Biol. 2017 Aug 21;27(16):2486-2498.e6. 


13. Cell-free reconstitution reveals centriole cartwheel assembly mechanisms. Guichard P*Hamel V*Le Guennec MBanterle NIacovache INemčíková VFlückiger IGoldie KNStahlberg HLévy DZuber BGönczy PNat Commun. 2017 Mar 23;8:14813.


12. Computational support for a scaffolding mechanism of centriole assembly. Klein HCGuichard PHamel V, Gönczy PSchwarz USSci Rep. 2016 Jun 8;6:27075. 


11. SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture. Hilbert M*Noga A*Frey D*Hamel V*Guichard PKraatz SHPfreundschuh MHosner SFlückiger IJaussi RWieser MMThieltges KMDeupi XMüller DJKammerer RAGönczy PHirono MSteinmetz MONat Cell Biol. 2016 Apr;18(4):393-403. 


10. Isolation, cryotomography, and three-dimensional reconstruction of centrioles. Guichard PHamel V, Neves AGönczy PMethods Cell Biol. 2015;129:191-209. 


9. Correlative multicolor 3D SIM and STORM microscopy. Hamel VGuichard PFournier MGuiet RFlückiger ISeitz AGönczy PBiomed Opt Express. 2014 Aug 29;5(10):3326-36. 


8. Mechanisms of HsSAS-6 assembly promoting centriole formation in human cells. Keller DOrpinell MOlivier NWachsmuth MMahen RWyss RHachet VEllenberg JManley SGönczy P. J Cell Biol. 2014 Mar 3;204(5):697-712. 


7. Native architecture of the centriole proximal region reveals features underlying its 9-fold radial symmetry. Guichard PHachet VMajubu NNeves ADemurtas DOlieric NFluckiger IYamada AKihara KNishida YMoriya SSteinmetz MOHongoh YGönczy PCurr Biol. 2013 Sep 9;23(17):1620-8. 


6. Caenorhabditis elegans centriolar protein SAS-6 forms a spiral that is consistent with imparting a ninefold symmetry. Hilbert M*Erat MC*Hachet V*Guichard PBlank IDFlückiger ISlater LLowe EDHatzopoulos GNSteinmetz MOGönczy PVakonakis IProc Natl Acad Sci U S A. 2013 Jul 9;110(28):11373-8. 


5. Cartwheel architecture of Trichonympha basal body. Guichard PDesfosses AMaheshwari AHachet V, Dietrich CBrune AIshikawa TSachse CGönczy PScience. 2012 Aug 3;337(6094):553. 


4. The nucleoporin Nup205/NPP-3 is lost near centrosomes at mitotic onset and can modulate the timing of this process in Caenorhabditis elegans embryos. Hachet VBusso CToya MSugimoto AAskjaer PGönczy PMol Biol Cell. 2012 Aug;23(16):3111-21. 


3. Centrosomes promote timely mitotic entry in C. elegans embryos. Hachet VCanard CGönczy PDev Cell. 2007 Apr;12(4):531-41.


2. Promotion of importin alpha-mediated nuclear import by the phosphorylation-dependent binding of cargo protein to 14-3-3. Faul CHüttelmaier SOh J, Hachet VSinger RHMundel P. J Cell Biol. 2005 May 9;169(3):415-24.


1. Importin alpha associates with membranes and participates in nuclear envelope assembly in vitro. Hachet VKöcher TWilm MMattaj IWEMBO J. 2004 Apr 7;23(7):1526-35.