Former groups

Katharina Strub

ks.jpgKatharina Strub was a Professor at the Department of Cell Biology, University of Geneva. Prof. Strub is a specialist in protein translation and her research focused in particular on the mechanisms that govern protein sorting and trafficking in the cell. 



Lab plasmids on Addgene




Alu RNA regulates the cellular pool of active ribosomes by targeted delivery of SRP9/14 to 40S subunits. Ivanova E, Berger A, Scherrer A, Alkalaeva E, Strub K. Nucleic Acids Res. 2015

Crystal structure of a signal recognition particle Alu domain in the elongation arrest conformation. Bousset L, Mary C, Brooks MA, Scherrer A, Strub K, Cusack S. RNA. 2014

Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocation. Lakkaraju AK, Thankappan R, Mary C, Garrison JL, Taunton J, Strub K. Mol Biol Cell. 2012

Multiple Roles of Alu-Related Noncoding RNAs. Berger A, Strub K. Prog Mol Subcell Biol. 2011

An Alu-like RNA promotes cell differentiation and reduces malignancy of human neuroblastoma cells. Castelnuovo M, Massone S, Tasso R, Fiorino G, Gatti M, Robello M, Gatta E, Berger A, Strub K, Florio T, Dieci G, Cancedda R, Pagano A. FASEB J. 2010

Structure of SRP14 from the Schizosaccharomyces pombe signal recognition particle. Brooks MA, Ravelli RB, McCarthy AA, Strub K, Cusack S. Acta Crystallogr D Biol Crystallogr. 2009

Characterization of APOBEC3G binding to 7SL RNA. Bach D, Peddi S, Mangeat B, Lakkaraju A, Strub K, Trono D. Retrovirology. 2008

Useful 'junk': Alu RNAs in the human transcriptome. Häsler J, Samuelsson T, Strub K. Cell Mol Life Sci. 2007. Review.

Alu elements as regulators of gene expression. Häsler J, Strub K. Nucleic Acids Res. 2006;34(19):5491-7. Epub 2006 Oct 4. Review. Erratum in: Nucleic Acids Res. 2007

Alu RNP and Alu RNA regulate translation initiation in vitro. Häsler J, Strub K. Nucleic Acids Res. 2006

Conserved tertiary base pairing ensures proper RNA folding and efficient assembly of the signal recognition particle Alu domain. Huck L, Scherrer A, Terzi L, Johnson AE, Bernstein HD, Cusack S, Weichenrieder O, Strub K. Nucleic Acids Res. 2004

Towards the structure of the mammalian signal recognition particle. Wild K, Weichenrieder O, Strub K, Sinning I, Cusack S. Curr Opin Struct Biol. 2002. Review.

Hierarchical assembly of the Alu domain of the mammalian signal recognition particle. Weichenrieder O, Stehlin C, Kapp U, Birse DE, Timmins PA, Strub K, Cusack S. RNA. 2001 

Structure and assembly of the Alu domain of the mammalian signal recognition particle. Weichenrieder O, Wild K, Strub K, Cusack S. Nature. 2000

Identification of a minimal Alu RNA folding domain that specifically binds SRP9/14. Weichenrieder O, Kapp U, Cusack S, Strub K. RNA. 1997

The crystal structure of the signal recognition particle Alu RNA binding heterodimer, SRP9/14. Birse DE, Kapp U, Strub K, Cusack S, Aberg A. EMBO J. 1997

An E. coli ribonucleoprotein containing 4.5S RNA resembles mammalian signal recognition particle. Poritz MA, Bernstein HD, Strub K, Zopf D, Wilhelm H, Walter P. Science. 1990 Nov 23;250(4984):

Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle. Bernstein HD, Poritz MA, Strub K, Hoben PJ, Brenner S, Walter P. Nature. 1989 Aug 10;340

Human SRP RNA and E. coli 4.5S RNA contain a highly homologous structural domain. Poritz MA, Strub K, Walter P. Cell. 1988 Oct 7;55(1):4-6.

Analogues and derivatives of tenoxicam. 1. Synthesis and antiinflammatory activity of analogues with different residues on the ring nitrogen and the amide nitrogen. Binder D, Hromatka O, Geissler F, Schmied K, Noe CR, Burri K, Pfister R, Strub K, Zeller P. J Med Chem. 1987 Apr;30(4):678-82.

Transcription termination and 3' processing: the end is in site! Birnstiel ML, Busslinger M, Strub K. Cell. 1985 Jun;41(2):349-59. Review.