Publications
*co-first author; +co-corresponding author
2022
2021
Antisense-mediated repression of SAGA-dependent genes involves the HIR histone chaperone. Soudet J.+, Beyrouthy N., Pastucha A.M., Maffioletti A., Bakir Z., Stutz F.+ BioRXiv. July 2021.
SUMO orchestrates multiple alternative DNA-protein crosslink repair pathways.
2020
Fine Chromatin-Driven Mechanism of Transcription Interference by Antisense Noncoding Transcription. Kaur Gill J., Maffioletti A., García-Molinero V., Stutz F.+, Soudet J.+. Cell Reports. 2020 May 5.
The aspartic protease Ddi1 contributes to DNA-protein crosslink repair in yeast.Molecular Cell, 2020.
2019
Regulation of Gene Expression and Replication Initiation by Non-Coding Transcription: A Model Based on Reshaping Nucleosome-Depleted Regions: Influence of Pervasive Transcription on Chromatin Structure. Soudet J, Stutz F. Bioessays. 2019 Nov 4
The functional complexity of the RNA-binding protein Yra1: mRNA biogenesis, genome stability and DSB repair. Infantino V, Stutz F. Curr Genet. 2019 Jul 10
The mRNA export adaptor Yra1 contributes to DNA double-strand break repair through its C-box domain. Infantino V, Tutucci E, Yeh Martin N, Zihlmann A, Garcia-Molinero V, Silvano G, Palancade B, Stutz F. PLOS One. 2019 April and
2018
Noncoding transcription influences the replication initiation program through chromatin regulation. Soudet J+, Gill JK, Stutz F+. Genome Res. 2018 Dec;28(12):1882-1893. doi: 10.1101/gr.239582.118. Epub 2018 Nov 6.
2017
Translesion synthesis DNA polymerase η exhibits a specific RNA extension activity and a transcription-associated function. Gali VK, Balint E, Serbyn N, Frittmann O, Stutz F, Unk I. Sci Rep. 2017 Oct 12;7(1):13055.
2015
Role of chromatin, environmental changes and single cell heterogeneity in non-coding transcription and gene regulation. Castelnuovo M and Stutz F. Curr Opin Cell Biol. 2015 Jun;34:16-22.
Sumoylation and transcription regulation at nuclear pores. Texari L, Stutz F. Chromosoma 2015 Mar;124(1):45-56. Review
2014
Role of histone modifications and early termination in pervasive transcription and antisense-mediated gene silencing in yeast. Castelnuovo M*, Zaugg JB*, Guffanti E*, Maffioletti A, Camblong J, Xu Z, Clauder-Münster S, Steinmetz LM, Luscombe NM, Stutz F. Nucleic Acids Res. 2014 Apr;42(7):4348-62.
2013
Bimodal expression of PHO84 is modulated by early termination of antisense transcription. Castelnuovo M*, Rahman S*, Guffanti E, Infantino V, Stutz F+, Zenklusen D+. Nat Struct Mol Biol. 2013 Jul;20(7):851-8.
Gene loops and HDACs to promote transcription directionality. Castelnuovo M, Stutz F. Nucleus 2013 Mar-Apr;4(2):92-4. doi: 10.4161/nucl.24236. Epub 2013 Mar 1.
The nuclear pore regulates GAL1 gene transcription by controlling the localization of the SUMO protease Ulp1. Texari L, Dieppois G, Vinciguerra P, Contreras MP, Groner A, Letourneau A, Stutz F. Mol Cell. 2013 Sep 26;51(6):807-18. doi: 10.1016/j.molcel.2013.08.047.
2012
Structural basis for polyadenosine-RNA binding by Nab2 Zn fingers and its function in mRNA nuclear export. Brockmann C, Soucek S, Kuhlmann SI, Mills-Lujan K, Kelly SM, Yang JC, Iglesias N, Stutz F, Corbett AH, Neuhaus D, Stewart M. Structure. 2012 Jun 6;20(6):1007-18.
Ubiquitin and assembly of export competent mRNP. Babour A, Dargemont C, Stutz F. Biochim Biophys Acta 2012 Jun;1819(6):521-30. Review.
2011
Keeping mRNPs in check during assembly and nuclear export. Tutucci E, Stutz F. Nat Rev Mol Cell Biol. 2011 Jun;12(6):377-84.
2010
Ubiquitin-mediated mRNP dynamics and surveillance prior to budding yeast mRNA export. Iglesias N*, Tutucci E*, Gwizdek C*, Vinciguerra P, Von Dach E, Corbett AH, Dargemont C, Stutz F. Genes Dev. 2010 Sep 1;24(17):1927-38. *Equal contribution.
Connecting the transcription site to the nuclear pore: a multi-tether process that regulates gene expression. Dieppois, G. and Stutz, F. Journal of Cell Science 2010 123: 1989-1999.
2009
Trans-acting antisense RNAs mediate transcriptional gene cosuppresion in S. cerevisiae. Camblong, J., Beyrouthy, N., Guffanti, E., Schlaepfer, G., Steinmetz, L. M., and Stutz, F. Genes Dev. 2009 23, 1534-1545.
Bidirectional promoters generate pervasive transcription in yeast. Xu, Z., Wei, W., Gagneur, J., Perocchi F., Clauder-Münster, C., Camblong, J., Guffanti, E., Stutz, F., Huber, W. and Steinmetz, L.M. Nature 2009 457, 1033-1037.
2008
Regulation of mRNP dynamics along the export pathway. Iglesias, N. and Stutz, F. FEBS Lett. 2008 582:1987-1996.
THO/sub2p functions to coordinate 3'-end processing with gene-nuclear pore association. Rougemaille, M., Dieppois, G., Kisseleva-Romanova, E., Gudipati, R.K., Lemoine, S., Blugeon, C., Boulay, J., Jensen, T.H., Stutz, F., Devaux, F. and Libri, D. Cell 2008 135:308-321.
2007
Anti-sense RNA stabilization induces transcriptional gene silencing via histone deacetylation in S. cerevisiae. Camblong, J., Iglesias, N., Fickentscher, C., Dieppois, G. and Stutz, F. Cell 2007, 131, 706-717.
Coordination of Hpr1 and ubiquitin binding by the UBA domain of the mRNA exort factor Mex67. Hobeika, M., Brockmann, C. Iglesias, N., Gwizdek, C., Neuhaus, D., Stutz, F., Stewart, M., Divita, G. and Dargemont C. Mol Biol Cell. 2007 18: 2561-2568.
2006
Co-transcriptional recruitment of the mRNA export receptor Mex67 contributes to nuclear pore anchoring of activated genes. *Dieppois,G., *Iglesias, N. and Stutz, F. Mol Cell Biol. 2006 26, 7858-7870. * Equal contribution
Ubiquitin-Associated domain of Mex67 synchronizes recruitment of the mRNA export machinery with transcription. *Gwizdek, C., *Iglesias, N., Rodriguez, M.S., Ossareh-Nazari, B, Hobeika, M., Divita, G., Stutz, F. and Dargemont, C. Proc Nat Acad Sci. 2006 103, 16376-16381. * Equal contribution
2005
Perinuclear Mlp proteins downregulate gene expression in response to a defect in mRNA export. Vinciguerra, P, Zenklusen, D., Iglesias, N and Stutz, F. EMBO J. 2005 24, 813-823.
2004
Nuclear export of RNA. Rodriguez M., Dargemont C. and Stutz F. Biology of the Cell 2004 96, 639-655.
mRNA export: an assembly line from genes to nuclear pores. Vinciguerra P. and Stutz F. 2004. Curr Op Cell Biol. 2004 16, 285-292.
Interactions of processed Nef (58-206) with virion proteins of HIV type 1. Ciuffi A, Munoz M, Bleiber G, Favre M, Stutz F, Telenti A, Meylan PR. AIDS Res Hum Retroviruses. 2004 Apr;20(4):399-407.
2003
Ubp3 requires a cofactor, Bre5, to specifically de-ubiquitinate the COPII protein, Sec23. Cohen M, Stutz F, Belgareh N, Haguenauer-Tsapis R, Dargemont C. Nat Cell Biol. 2003 5, 661-7.
Deubiquitination, a new player in Golgi to endoplasmic reticulum retrograde transport. Cohen M, Stutz F, Dargemont C. J Biol Chem. 2003 278, 51989-92.
The interplay of nuclear mRNP assembly, surveillance and export. Stutz F. and Izaurralde E. Trends in Cell Biol. 2003 13, 319-327.
2002
Coupling of termination, 3' processing, and mRNA export. Hammell CM, Gross S, Zenklusen D, Heath CV, Stutz F, Moore C, Cole CN. Mol Cell Biol. 2002 Sep;22(18):6441-57.
Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p. Zenklusen D, Vinciguerra P, Wyss JC, Stutz F. Mol Cell Biol. 2002 Dec;22(23):8241-53.
Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1. Le Rouzic E, Mousnier A, Rustum C, Stutz F, Hallberg E, Dargemont C, Benichou S. J Biol Chem. 2002 Nov 22;277(47):45091-8. Epub 2002 Sep 12.
2001
mRNA export: travelling with DEAD box proteins. Linder P, Stutz F. Curr Biol. 2001 Nov 27;11(23):R961-3. Review.
Nuclear export of mRNA. Zenklusen D, Stutz F. FEBS Lett. 2001 Jun 8;498(2-3):150-6. Review.
The yeast hnRNP-Like proteins Yra1p and Yra2p participate in mRNA export through interaction with Mex67p. Zenklusen D, Vinciguerra P, Strahm Y, Stutz F. Mol Cell Biol. 2001 Jul;21(13):4219-32.
2000
Yeast Ran-binding protein 1 (Yrb1) shuttles between the nucleus and cytoplasm and is exported from the nucleus via a CRM1 (XPO1)-dependent pathway. Künzler M, Gerstberger T, Stutz F, Bischoff FR, Hurt E. Mol Cell Biol. 2000 Jun;20(12):4295-308.
REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export. Stutz F, Bachi A, Doerks T, Braun IC, Séraphin B, Wilm M, Bork P, Izaurralde E. RNA. 2000 Apr;6(4):638-50.
1999
The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr 255p. Strahm Y, Fahrenkrog B, Zenklusen D, Rychner E, Kantor J, Rosbash M, Stutz F. EMBO J. 1999 Oct 15;18(20):5761-77.
1998
Nuclear RNA export. Stutz F and Rosbash M. Genes Dev. 1998 Nov 1;12(21):3303-19.