Françoise Stutz - Director


*co-first author; +co-corresponding author


Antisense-mediated repression of SAGA-dependent genes involves the HIR histone chaperone.  Soudet J.+Beyrouthy N.Pastucha AM.Maffioletti A.Menéndez D.Bakir Z.Stutz F.+. Nucleic Acids Res. April 2022. doi: 10.1093/nar/gkac264


Antisense-mediated repression of SAGA-dependent genes involves the HIR histone chaperone. Soudet J.+, Beyrouthy N., Pastucha A.M., Maffioletti A., Bakir Z., Stutz F.+ BioRXiv. July 2021. 

SUMO orchestrates multiple alternative DNA-protein crosslink repair pathways. Serbyn N.+Bagdiul I.Michel AH.Suhandynata RT.Zhou H,. Kornmann B.Stutz F+. Cell Reports. 2021 Nov 23


Fine Chromatin-Driven Mechanism of Transcription Interference by Antisense Noncoding TranscriptionKaur Gill J., Maffioletti A., García-Molinero V., Stutz F.+, Soudet J.+. Cell Reports. 2020 May 5.

The aspartic protease Ddi1 contributes to DNA-protein crosslink repair in yeast. Serbyn N+Noireterre A, Bagdiul IPlank MMichel AHLoewith R, Kornmann BStutz F+. Molecular Cell, 2020. 


Regulation of Gene Expression and Replication Initiation by Non-Coding Transcription: A Model Based on Reshaping Nucleosome-Depleted Regions: Influence of Pervasive Transcription on Chromatin Structure. Soudet J, Stutz F. Bioessays. 2019 Nov 4

The functional complexity of the RNA-binding protein Yra1: mRNA biogenesis, genome stability and DSB repair. Infantino V, Stutz FCurr Genet. 2019 Jul 10

The mRNA export adaptor Yra1 contributes to DNA double-strand break repair through its C-box domain. Infantino V, Tutucci E, Yeh Martin N, Zihlmann A, Garcia-Molinero V, Silvano G, Palancade B, Stutz F. PLOS One. 2019 April and 


Noncoding transcription influences the replication initiation program through chromatin regulation. Soudet J+, Gill JK, Stutz F+. Genome Res. 2018 Dec;28(12):1882-1893. doi: 10.1101/gr.239582.118. Epub 2018 Nov 6.


Translesion synthesis DNA polymerase η exhibits a specific RNA extension activity and a transcription-associated functionGali VKBalint ESerbyn NFrittmann OStutz FUnk I. Sci Rep. 2017 Oct 12;7(1):13055.


Role of chromatin, environmental changes and single cell heterogeneity in non-coding transcription and gene regulation. Castelnuovo M and Stutz F. Curr Opin Cell Biol. 2015 Jun;34:16-22.

Sumoylation and transcription regulation at nuclear pores. Texari LStutz FChromosoma 2015 Mar;124(1):45-56. Review


Role of histone modifications and early termination in pervasive transcription and antisense-mediated gene silencing in yeast. Castelnuovo M*Zaugg JB*Guffanti E*Maffioletti ACamblong JXu ZClauder-Münster SSteinmetz LMLuscombe NMStutz FNucleic Acids Res. 2014 Apr;42(7):4348-62.


Bimodal expression of PHO84 is modulated by early termination of antisense transcription. Castelnuovo M*Rahman S*Guffanti EInfantino VStutz F+Zenklusen D+Nat Struct Mol Biol. 2013 Jul;20(7):851-8.

Gene loops and HDACs to promote transcription directionality. Castelnuovo MStutz FNucleus 2013 Mar-Apr;4(2):92-4. doi: 10.4161/nucl.24236. Epub 2013 Mar 1.

The nuclear pore regulates GAL1 gene transcription by controlling the localization of the SUMO protease Ulp1. Texari L, Dieppois G, Vinciguerra P, Contreras MP, Groner A, Letourneau A, Stutz F. Mol Cell. 2013 Sep 26;51(6):807-18. doi: 10.1016/j.molcel.2013.08.047.


Structural basis for polyadenosine-RNA binding by Nab2 Zn fingers and its function in mRNA nuclear export. Brockmann CSoucek SKuhlmann SIMills-Lujan KKelly SMYang JCIglesias NStutz FCorbett AHNeuhaus DStewart MStructure. 2012 Jun 6;20(6):1007-18. 

Ubiquitin and assembly of export competent mRNP. Babour ADargemont CStutz FBiochim Biophys Acta 2012 Jun;1819(6):521-30. Review.


Keeping mRNPs in check during assembly and nuclear export. Tutucci EStutz FNat Rev Mol Cell Biol. 2011 Jun;12(6):377-84.


Ubiquitin-mediated mRNP dynamics and surveillance prior to budding yeast mRNA export. Iglesias N*Tutucci E*Gwizdek C*, Vinciguerra PVon Dach ECorbett AHDargemont CStutz FGenes Dev. 2010 Sep 1;24(17):1927-38.  *Equal contribution.

Connecting the transcription site to the nuclear pore: a multi-tether process that regulates gene expression. Dieppois, G. and Stutz, F. Journal of Cell Science 2010 123: 1989-1999.


Trans-acting antisense RNAs mediate transcriptional gene cosuppresion in S. cerevisiae. Camblong, J., Beyrouthy, N., Guffanti, E., Schlaepfer, G., Steinmetz, L. M., and Stutz, F. Genes Dev. 2009 23, 1534-1545.

Bidirectional promoters generate pervasive transcription in yeast. Xu, Z., Wei, W., Gagneur, J., Perocchi F., Clauder-Münster, C., Camblong, J., Guffanti, E., Stutz, F., Huber, W. and Steinmetz, L.M. Nature 2009 457, 1033-1037.


Regulation of mRNP dynamics along the export pathway. Iglesias, N. and Stutz, F. FEBS Lett. 2008 582:1987-1996.

THO/sub2p functions to coordinate 3'-end processing with gene-nuclear pore association. Rougemaille, M., Dieppois, G., Kisseleva-Romanova, E., Gudipati, R.K., Lemoine, S., Blugeon, C., Boulay, J., Jensen, T.H., Stutz, F., Devaux, F. and Libri, D.  Cell 2008 135:308-321.


Anti-sense RNA stabilization induces transcriptional gene silencing via histone deacetylation in S. cerevisiae. Camblong, J., Iglesias, N., Fickentscher, C., Dieppois, G. and Stutz, F. Cell 2007, 131, 706-717.

Coordination of Hpr1 and ubiquitin binding by the UBA domain of the mRNA exort factor Mex67. Hobeika, M., Brockmann, C. Iglesias, N., Gwizdek, C., Neuhaus, D., Stutz, F., Stewart, M., Divita, G. and Dargemont C. Mol Biol Cell. 2007 18: 2561-2568.


Co-transcriptional recruitment of the mRNA export receptor Mex67 contributes to nuclear pore anchoring of activated genes. *Dieppois,G., *Iglesias, N. and Stutz, F. Mol Cell Biol. 2006 26, 7858-7870. * Equal contribution

Ubiquitin-Associated domain of Mex67 synchronizes recruitment of the mRNA export machinery with transcription. *Gwizdek, C., *Iglesias, N., Rodriguez, M.S., Ossareh-Nazari, B, Hobeika, M., Divita, G., Stutz, F. and Dargemont, C. Proc Nat Acad Sci. 2006 103, 16376-16381. * Equal contribution


Perinuclear Mlp proteins downregulate gene expression in response to a defect in mRNA export. Vinciguerra, P, Zenklusen, D., Iglesias, N and Stutz, F. EMBO J. 2005 24, 813-823.


Nuclear export of RNA. Rodriguez M., Dargemont C. and Stutz F. Biology of the Cell 2004 96, 639-655.

mRNA export: an assembly line from genes to nuclear pores. Vinciguerra P. and Stutz F. 2004. Curr Op Cell Biol. 2004 16, 285-292.

Interactions of processed Nef (58-206) with virion proteins of HIV type 1. Ciuffi A, Munoz M, Bleiber G, Favre M, Stutz F, Telenti A, Meylan PR. AIDS Res Hum Retroviruses. 2004 Apr;20(4):399-407.


Ubp3 requires a cofactor, Bre5, to specifically de-ubiquitinate the COPII protein, Sec23. Cohen M, Stutz F, Belgareh N, Haguenauer-Tsapis R, Dargemont C. Nat Cell Biol. 2003 5, 661-7.

Deubiquitination, a new player in Golgi to endoplasmic reticulum retrograde transport. Cohen M, Stutz F, Dargemont C. J Biol Chem. 2003 278, 51989-92.

The interplay of nuclear mRNP assembly, surveillance and export. Stutz F. and Izaurralde E. Trends in Cell Biol. 2003 13, 319-327.


Coupling of termination, 3' processing, and mRNA export. Hammell CM, Gross S, Zenklusen D, Heath CV, Stutz F, Moore C, Cole CN. Mol Cell Biol. 2002 Sep;22(18):6441-57.

Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p. Zenklusen D, Vinciguerra P, Wyss JC, Stutz F. Mol Cell Biol. 2002 Dec;22(23):8241-53.

Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1. Le Rouzic E, Mousnier A, Rustum C, Stutz F, Hallberg E, Dargemont C, Benichou S. J Biol Chem. 2002 Nov 22;277(47):45091-8. Epub 2002 Sep 12.


mRNA export: travelling with DEAD box proteins. Linder P, Stutz F. Curr Biol. 2001 Nov 27;11(23):R961-3. Review.

Nuclear export of mRNA. Zenklusen D, Stutz F. FEBS Lett. 2001 Jun 8;498(2-3):150-6. Review.

The yeast hnRNP-Like proteins Yra1p and Yra2p participate in mRNA export through interaction with Mex67p. Zenklusen D, Vinciguerra P, Strahm Y, Stutz F. Mol Cell Biol. 2001 Jul;21(13):4219-32.


Yeast Ran-binding protein 1 (Yrb1) shuttles between the nucleus and cytoplasm and is exported from the nucleus via a CRM1 (XPO1)-dependent pathway. Künzler M, Gerstberger T, Stutz F, Bischoff FR, Hurt E. Mol Cell Biol. 2000 Jun;20(12):4295-308.

REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export. Stutz F, Bachi A, Doerks T, Braun IC, Séraphin B, Wilm M, Bork P, Izaurralde E. RNA. 2000 Apr;6(4):638-50.


The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr 255p. Strahm Y, Fahrenkrog B, Zenklusen D, Rychner E, Kantor J, Rosbash M, Stutz F. EMBO J. 1999 Oct 15;18(20):5761-77.


Nuclear RNA export. Stutz F and Rosbash M. Genes Dev. 1998 Nov 1;12(21):3303-19.