We use the budding yeast as a model system to study the process of mRNA biogenesis and export through nuclear pores, and the importance of nuclear architecture in gene expression. Another topic concerns the role of pervasive non-coding transcription in gene regulation. More recently, we have become interested in the factors involved in DNA-protein crosslink (DPC) repair and genome stability.
Research projects include:
- Role of ubiquitin in the regulation of mRNP dynamics and export through nuclear pores.
- Functional relationship between gene expression and intra-nuclear gene positioning: role of nuclear pores in transcription regulation?
- Importance of non-coding and antisense RNAs in epigenetic control of gene expression through RNAi independent mechanisms.
- Identification of new factors involved in DPC repair using SATAY transposon screens.