Research Groups

Ivana Gasic - SNSF Eccellenza (from 2021)

In our lab we challenge the central dogma postulating that regulation of gene expression and protein quantity is a unidirectional process. We have recently shown how tubulin protein quantity feeds back into its encoding mRNA stability via a specificity factor. Our goal is to reveal how cells control protein quantity to ensure homeostasis. To address the functional aspects of protein quantity control, we love fluorescent imaging of live and fixed mammalian cultured cells. 

Our favourite proteins are tubulins—the main constituents of the microtubule cytoskeleton. Tubulins are amongst the most abundant proteins in cells (making ~1% of cellular proteome!). They exist as soluble heterodimers and polymers known as microtubules. Microtubules are exceptionally dynamic, undergoing phases of growth and shrinkage. And so they re-invent themselves over and over, to respond to cellular needs. These properties, combined with exceptional chemical tools to manipulate them make tubulins and microtubules an ideal system to study how protein quantity is achieved and how it impacts cellular functions. Under the microscope, microtubules resemble a cob web, and when filmed live in partnership with their end-binding proteins they throw a real fireworks show.

 

But we understand that the world doesn't spin around tubulins and are eager to welcome new fellows whose precise quantity is key to cellular happiness. To learn more about us, read on or visit us in the beautiful international city of Geneva in Switzerland, at the Faculty of Sciences.

PUBLICATIONS
 
Tubulin Resists Degradation by Cereblon-Recruiting PROTACs.
Gasic I, Groendyke BJ, Nowak RP, Yuan JC, Kalabathula J, Fischer ES, Gray NS, Mitchison TJ. Cells. 2020 Apr 27
 
TTC5 mediates autoregulation of tubulin via mRNA degradation.
Lin Z, Gasic I, Chandrasekaran V, Peters N, Shao S, Mitchison TJ, Hegde RS. Science. 2020 Jan 3
  
Autoregulation and repair in microtubule homeostasis.
Gasic I, Mitchison TJ. Curr Opin Cell Biol. 2019 Feb.  Review.
 
The Ska complex promotes Aurora B activity to ensure chromosome biorientation.
Redli PM, Gasic I, Meraldi P, Nigg EA, Santamaria A. J Cell Biol. 2016 Oct 10
 
The equatorial position of the metaphase plate ensures symmetric cell divisions.
Tan CH, Gasic I, Huber-Reggi SP, Dudka D, Barisic M, Maiato H, Meraldi P. Elife. 2015 Jul 18
 
Nonautonomous movement of chromosomes in mitosis.
Vladimirou E, Mchedlishvili N, Gasic I, Armond JW, Samora CP, Meraldi P, McAinsh AD. Dev Cell. 2013 Oct 14