Guichard / Hamel

Paul Guichard

Prof. Paul Guichard

Associate Professor

+41 22 379 6750

Professeur associé / Associate Professor

Mini CV

Since 2021 - Associate Professor

2015-2021- SNSF Professor, Assistant Professor Tenure Track 

2011-2015 -Post-doc, EPFL Switzerland 

2010  - PhD Institut Curie. France



2022              Friedrich Miescher Award     

2020-2024  EMBO YIP

2017-2022   ERC Starting Grant

2015-2019   SNSF Professorship

2012-2014   EMBO long-term Fellowship

2007-2010  PhD Fellowship - French government


 Selected publications:

Visualizing the native cellular organization by coupling cryo-fixation with expansion microscopy (Cryo-ExM)Laporte M.H., Klena N., Hamel V* and Guichard P*. Nature Methods. Jan 2022. 
A helical inner scaffold provides a structural basis for centriole cohesion. Le Guennec M, Klena N., Gambarotto D., Laporte MH , Tassin AM, Van den Hoek H., Erdmann PS, Schaffer M., Kovacik L., Borgers S., Goldie KN, Stahlberg H., Bornens M., Azimzadeh J., Engel BD#, Hamel V.* and Guichard P.Science Advances. Feb 2020

Flagellar microtubule doublet assembly in vitro reveals a regulatory role of tubulin C-terminal tails.  M. Schmidt-Cernohorska, I. Zhernov, E. Steib, M. Le Guennec1, R. Achek, S. Borgers, D. Demurtas, L. Mouawad, Z. Lansky, V. Hamel* and P. Guichard*.  Science. Jan 2019

Imaging cellular ultrastructures using expansion microscopy (U-ExM).  Gambarotto D. ##, Zwettler F. U. ##, Schmidt-Cernohorska M. , Fortun D. , Borgers  S. , Heine J. , Schloetel J. G. , Reuss M. , Unser M. , Boyden E.S. , Sauer M. *, Hamel V. * and  Guichard P.*. Nature Methods. 2019

Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis. Hamel V, Steib E, Hamelin R, Armand F, Borgers S, Flückiger I, Busso C, Olieric N, Sorzano COS, Steinmetz MO, Guichard P*, Gönczy P.* Curr Biol. 2017 Aug 21

Cell-free reconstitution reveals centriole cartwheel assembly mechanisms. Guichard P, Hamel V, Le Guennec M, Banterle N, Iacovache I, Nemčíková V, Flückiger I, Goldie KN, Stahlberg H, Lévy D, Zuber B, Gönczy P. Nat Commun. 2017 Mar 23

Native architecture of the centriole proximal region reveals features underlying its 9-fold radial symmetry. Guichard P, Hachet V, Majubu N, Neves A, Demurtas D, Olieric N, Fluckiger I, Yamada A, Kihara K, Nishida Y, Moriya S, Steinmetz MO, Hongoh Y, Gönczy P. Curr Biol. 2013 Sep 9

Cartwheel architecture of Trichonympha basal body. Guichard P, Desfosses A, Maheshwari A, Hachet V, Dietrich C, Brune A, Ishikawa T, Sachse C, Gönczy P. Science. 2012 Aug 3

Procentriole assembly revealed by cryo-electron tomography. Guichard P, Chrétien D, Marco S, Tassin AM. EMBO J. 2010 May 5